There are over 100 different liver diseases that affect children today. The incidence of pediatric liver disease is 1 in 25,000 births in the United States. In children, liver disease can be caused by a viral infection, genetic factors, immune disorders, or often times a cause unknown. Pediatric liver disease alone causes over 15,000 hospital admissions each year. These admissions range from the treatment of infections, bleeding problems related to a poorly functioning liver, nutritional problems, further diagnostic testing and transplant as well as many others. Between 500-600 children undergo a liver transplant every year in the United States. The outcome for children with end stage liver disease has dramatically improved as medicine has advanced in recent years. Children today are fortunate that transplantation and anti-rejection medications are highly successful and can provide them the opportunity to experience happy and active lives.